AChE, NMDAR, β-secretase, Aβ oligomers, Aβ plaques, GSK-3β, neurofibrillary tangles, Ca2+ ions, and reactive oxygen species are elements involved in the pathogenesis of Alzheimer’s disease (AD) and represent significant potential targets for treatment (105). Here, GSK3B is linked to early-onset autosomal dominant Alzheimer disease.