Previous studies showed that the activation of the NLRP3 inflammasome is associated with the accumulation of α-synuclein aggregates, and these studies further confirmed the role of NLRP3 in amyloid β and tau driving in Alzheimer’s disease (Gordon et al., 2018; Anderson et al., 2023). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.