In summary, our dynamic Boolean network, based on clinical data and experimental observations, reveals novel positive circuits: miR-145/Sp1/MALAT1, BMI1/miR-145/Myc, KLF4/p53/miR-145, and miR-145/Wip1/p38MAPK/p53, all contributing to drug resistance in NSCLC. This evidence concerns the gene KLF4 and non-small cell lung carcinoma.