After that, Chen et al. [4] showed that Myc is upregulated (E1) in NSCLC cells and that miR-145 directly targets Myc and Cdk4,6/cyclin D in response to DNA damage, inhibits tumor growth, and induces senescence (see Fig. 2, underlined in the purple circles). This evidence concerns the gene MYC and non-small cell lung carcinoma.