SOCS1 and Alzheimer disease: He et al. reported that ethyl vanillin oxime vanadium could inhibit the cytokine signaling transduction suppressor of cytokine signaling 1/Janus kinase 2/signal transduction and activator of transcription 3 (SOCS-1/JAK2/STAT3) signaling pathway and block the cascade reaction of amyloidosis in AD mouse models, thereby reducing Aβ-induced insulin resistance in AD models [56].