LPAR1 and Alzheimer disease: Wu et al. demonstrated that circular RNA recombinant lysophosphatidic acid receptor 1 (circRNA LPAR1) promotes neuronal apoptosis, inflammation, and oxidative stress induced by Aβ25-35 via the miR-212–3p/zinc finger protein 217 (ZNF217) axis, contributing to the development of AD (Fig. 3) [82].