Li et al. found that circular RNA PTK receptor gene (circAXL), circular RNA gephyrin gene (circGPHN), and circular RNA inositol 1,4,5-trisphosphate receptor type 3 (circ-ITPR3) are independent risk factors for AD based on the analysis of the circRNA expression profile in the cerebrospinal fluid of AD patients [81]. The gene discussed is ITPR3; the disease is Alzheimer disease.