SLC38A8 has a high GWAS Catalog score (14.1) with adiponectin measurement (Spracklen et al., 2019), which directly affects insulin sensitivity and obesity, and a strong association with eye diseases, e.g., foveal hypoplasia 2 and anterior segment dysgenesis. This evidence concerns the gene SLC38A8 and obesity due to melanocortin 4 receptor deficiency.