CDKN2A and hereditary clear cell renal cell carcinoma: In addition to this, in NONO-TFE3 fused renal cell carcinoma, circMET recruits YTHDF2 by directly binding CDKN2A mRNA, which significantly impairs CDKN2A expression and leads to CDKN2A mRNA attenuation (Yang et al., 2021b).