According to research, circRHBDD1 increases the metabolic reprogramming of HCC and reduces the effectiveness of anti-PD-1 treatment by attaching YTHDF1 to PIK3R1 mRNA and accelerating PIK3R1 translation in a way that depends on m6A (Cai et al., 2022). The gene discussed is PIK3R1; the disease is hepatocellular carcinoma.