Interestingly, Liyan Wang et al. discovered that exosomes produced from M1 macrophages transported miR-628-5p to hepatocellular carcinoma cells to restrict METTL14 expression, which lowered the degree of circFUT8 m6A modification, hence reducing HCC growth (Wang et al., 2022b). The gene discussed is METTL14; the disease is hepatocellular carcinoma.