PKM and hepatocellular carcinoma: In addition to this, METTL3 maintains the upregulation of LNCAROD by increasing m6A methylation-mediated RNA stability, while LNCAROD increases PKM2 levels by simultaneously enhancing SRSF3-mediated PKM to PKM2 conversion and uptake of miR-145-5p to increase PKM2 levels, ultimately increasing aerobic glycolysis in HCC cells (Jia et al., 2021).