Figure 5(a) shows 12 frequently mutated genes; APIK3CA, TP53, and GATA3 ranked the first three mutational genes.  Figure 5(b) compared the significantly different somatic mutations in DJ-1 high and low expression subsets; mutations in TFAP2A, DLGAP2, and CCDC144A were most highly enriched in high DJ-1 expression subpopulation. A total of six mutations in TFAP2A were detected, including five missense and one truncating (Figure 5(c)). The top 20 mutated genes in HR+ breast cancer, HER2+ breast cancer, and TNBC patients from the TCGA database were shown in Supplementary 4. This evidence concerns the gene TFAP2A and breast carcinoma.