It is reported that among those SLE patients with joint involvement, EA may exceed 30%.[3,4] Researchers attempted to discover biomarkers associated with EA in SLE, and the suggested predictors or indicators include anti–citrullinated protein antibodies (ACPA),[5,6] anti– carbamylated proteins[7] in serum, elevated IL-17 in synovial fluid,[8] and amount of Porphyromonas gingivalis in the tongue biofilm.[9]. This evidence concerns the gene PRTN3 and systemic lupus erythematosus.