RO60 and systemic lupus erythematosus: In one compelling example, Ro60, which is an RNA binding protein that is a common target of autoantibody responses in patients with lupus and Sjogren’s syndrome, was shown to also become recognized by specific T cells in lupus-prone mice colonized with commensal bacteria that naturally express Ro60 orthologs.[50,51] Notably, depletion of Ro60 ortholog-expressing bacteria reduced the in vivo representation of activated Ro60-specific T cells.[50]