While we uncovered an interesting property of the highly metastatic and representative triple-negative breast cancer cell line, MDA-MB-231, in which they can be primed in a vinculin-dependent manner to increase active mitochondrial polarization in confining regions of increased matrix contact, the mechanism by which vinculin and mitochondria interact to facilitate fast migration is still not fully understood. Here, VCL is linked to triple-negative breast carcinoma.