We report that the combinatorial therapy strategy suggested here moderated the immunohistochemical reaction of caspase-3 and cyclooxygenase-2 (COX-2) compared to a significant increase in the DMBA carcinogenesis group, decreased the expression of the anti-apoptotic protein (BCL-2), and increased the immunohistochemistry of GATA-3 as a diagnostic marker for mammary cancer metastases.51–53 The TEM demonstrated the existence of tissue macrophages and lymphocytes linked to local dendritic cell (DC) activation and promoted DC migration to the lymphoid tissue containing their tumor antigens. Here, CASP3 is linked to breast cancer.