CD4 and infection: In this regard, associations with greater pathogenic potentials have been reported for CRF14_BG (Pérez-Álvarez et al., 2014) CRF19_cpx (Kouri et al., 2015), a CRF01_AE cluster (Song et al., 2019; Ge et al., 2021), and a subtype B cluster (Wymant et al., 2022), and CRF55_01B has been associated with lower CD4 T-cell counts than those found in CRF07_BC infections and higher viral loads than those found in CRF01_AE and CRF07_BC infections (Wei et al., 2021).