However, AD was mainly injured in bilateral PCUN and partial lobes, including posterior cingulate gyrus, PCUN, parietal lobe and part of occipital lobe, resulting in multi-dimensional functional damage in language, memory, learning, vision, etc. Only a small proportion (56 voxels in total) of MOG.R belonged to a part of the visual cortex were found in these two diseases, which was consistent with the clinical characteristics of them, and also suggested that T2DM was a risk factor for AD. This evidence concerns the gene MOG and Alzheimer disease.