Familial tau and presenilin mutations to promote EV mediation of tau propagation in the brain. EVs generated by neurons expressing familial mutations of tauopathies, human iPSC neurons expressing mTau with the P301L and V337M mutations of FTDP[26,27], and mPS1 with the A246E mutation of AD[28], were assessed for initiation of tau propagation in mouse brain and were subjected to proteomics and bioinformatics to analyze proteome cargoes [Figure 1]. The gene discussed is MAPT; the disease is Alzheimer disease.