SERMs: Selective estrogen receptor modulator, HRT: Hormonal replacement therapy, BMD: Bone mineral density, CCR: Continuous combined regimen, HT: Hormonal therapy, ER: Estrogen receptor, GSM: Genitourinary syndrome of menopause, DHEAS: Dehydroepiandrosterone sulfate, VVA: Vulvovaginal atrophy, CVD: Cardiovascular diseases, pH: Potential of Hydrogen. The gene discussed is ESR1; the disease is cardiovascular disorder.