Of the features selected by the model built on samples from the UOP cohort, five independently validated on samples from the STA cohort including CD4+ T cell size and density in the stroma, neighborhood relationship between regulatory CD4+ T cells and non-proliferating tumor cells, and cell densities of non-proliferating tumor cells in the tumor core and proliferating tumor cells at the tumor front (Figures 5 and S10). Here, CD4 is linked to neoplasm.