Examination of the phenotypic organization across the UOP OSCC biopsies revealed that of the 15 cell subsets characterized, the most abundant cell population was non-proliferating tumor cells (24.8%), while immune infiltrates were mainly composed of CD8+ T cells (8.4%), memory CD4+ T cells (5.7%), and M1 macrophages (3.4%). This evidence concerns the gene CD4 and neoplasm.