In enteroids from patients with obesity, SCFAs (1 mM) increased (p < 0.05) ALPI mRNA expression 2.9-fold, but decreased (p < 0.01) MUC2 (0.4-fold) and CHGA (0.3-fold) mRNA expression. This evidence concerns the gene ALPI and obesity due to melanocortin 4 receptor deficiency.