A critical role of IL-33 signaling in Tollip deficiency-mediated amplification of type 2 inflammation was supported by our data showing that sST2, a decoy IL-33 receptor ST2L (41), significantly reduced eosinophilic inflammation, Muc5ac and IL-5 expression. Here, MUC5AC is linked to hyperinsulinemic hypoglycemia, familial, 4.