Meanwhile, our data also revealed that the expression of Perforin (Figure 7B) and Granzyme B (Figure 7C) in splenic CD8+ T lymphocytes from the mice in the MSCs group and MEXs group were notably higher than that in the BMCs group, and no differences were observed among the other three groups, indicating that administration of MSCs and MEXs could not affect the anti-leukemia activity of CD8+ T lymphocytes from recipients. The gene discussed is PRF1; the disease is leukemia.