CREBBP and diffuse large B-cell lymphoma: From a modeling point of view, it is important to note that homo- or heterozygous Crebbp-deficiency (in Cd19Cre/wt;Crebbpfl/fl or Cd19Cre/wt;Crebbpfl/wt and Cγ1Cre;Crebbpfl/fl or Cγ1Cre;Crebbpfl/wt mice) did not lead to significant lymphoma (FL/DLBCL) development (51).