Of note, reminiscent of the conditional Kmt2d knockout mice, when Ezh2Y641F mice were crossed with Cd19Cre animals in which recombination occurs at early B cell developmental stages, the resulting Cd19Cre/wt;Ezh2Y641F/wt mice develop DLBCL within 12 months (54). This evidence concerns the gene KMT2D and diffuse large B-cell lymphoma.