The oncogenic potential of the BTG1 p.Q36H mutation was further investigated in a bone marrow chimera setting, where recipients transplanted with Cγ1Cre/wt;VavP-BCL2;Rosa26LSL.BTG1.G36H/wt HSCs developed clonal DLBCL-like lymphoma with evidence of somatic hypermutation and passed away significantly earlier than Cγ1wt/wt;VavP-BCL2;Rosa26LSL.BTG1.G36H/wt and Cγ1wt/wt;Rosa26LSL.BTG1.G36H/wt controls (64). Here, BCL2 is linked to diffuse large B-cell lymphoma.