EZH2 and lymphoma: By using the above-mentioned HSC transplant experiments, as well as the autochthonous Cγ1Cre;VavP-BCL2;Ezh2Y641F/wt and Cγ1Cre;VavP-BCL2;Ezh2Y641N/wt models, it was shown that expression of the MHCI and MHCII antigen presentation machinery was substantially reduced in Ezh2-mutant lymphoma cells, compared to wildtype controls (102).