TET2 and lymphoma: Consistent with the impaired GC exit phenotype in Cd19Cre;Tet2fl/fland VavCre;Tet2fl/flmice, Tet2 deficiency was associated with reduced enhancer cytosine hydroxymethylation and reduced expression of genes that promote GC exit, such as Prdm1, in these settings (62). A further analysis revealed that there is substantial overlap of the enhancers and genes that are repressed in Tet2-deficient settings and CREBBP-mutant lymphomas, suggesting a similarly rewired transcriptome that is brought about by these distinct genomic lesions (62).