When four hallmark genetic aberrations in C5/MCD DLBCL were modelled in AicdaCre/wt;Myd88p.L252P/wt;Cd79bp.Y195H/wt;Rosa26LSL.BCL2.IRES.GFP/wt;Prdm1fl/fl mice, these animals displayed a drastically increased in GC size and number at 8 weeks of age, compared to controls (65). Here, BCL2 is linked to diffuse large B-cell lymphoma.