There were no significant survival differences between Cγ1Cre;Crebbpfl/wt;VavP-BCL2 and Cγ1Cre;Crebbpwt/wt;VavP-BCL2 animals, which is likely due to the development of glomerulonephritis and other autoimmune diseases that develop in VavP-BCL2 mice with almost 100% penetrance (47). The gene discussed is BCL2; the disease is autoimmune disease.