In line with transcriptional rewiring downstream of mutant Tbl1xr1, RNA-Seq analysis of GC B cells derived from these animals revealed an enrichment for ABC-DLBCL-associated gene expression signatures and NF-kB signaling, which are normally repressed in GC B by the BCL6-SMRT complex (70). Here, NCOR2 is linked to diffuse large B-cell lymphoma.