Biochemical experiments using a TBL1XR1 p.Y446S mutant, which frequently occurs in human DLBCL, revealed that although the interaction with the SMRT/HDAC3 complex was preserved, the only significant change in the TBL1XR1mut interactome was a robust shift away from an interaction with BCL6 towards an interaction with the transcription factor BACH2 (70), which plays a critical role in memory B cell generation (130). Here, TBL1XR1 is linked to diffuse large B-cell lymphoma.