BCL2 and autoimmune disease: It is important to note that these results are likely confounded by the development of glomerulonephritis and other autoimmune diseases which occur in VavP-BCL2 mice with almost 100% penetrance, resulting in a median survival of around 6 to 9 months, representing a limiting factor for employing this allele in the study of GC B cell lymphomagenesis (47, 55, 61, 64, 109).