BCL2 and neoplasm: Further support for a tumor-suppressive role of TBL1XR1 stems from the analysis of immunized VavP-BCL2;Cd19Cre/wt;Tbl1xr1fl/fl animals, which were shown to develop predominantly extra-nodal lymphomas, at a time point at which no tumors were detectable in VavP-BCL2;Cd19Cre/wt controls (70).