In line with their GC origin, Burkitt lymphomas (BL), follicular lymphomas (FL) and diffuse large B cell lymphomas (DLBCL) are GC-experienced, as evidenced by somatic hypermutation (SHM)-mediated mutagenesis within their BCR variable regions – an irreversible marker of GC passage (5–8). The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.