Moreover, the multivariate analysis showed that the lines of treatment [PFS: HR(95%CI):0.154(0.094-0.252), P=0.000; OS: HR(95%CI):0.184(0.099-0.344), P=0.000], metastases [PFS: HR(95%CI):3.432(2.292-5.140), P=0.000; OS: HR(95%CI):5.054(3.019-8.458), P=0.000], and PD-L1 expression [PFS: HR(95%CI):0.277(0.144-0.531), P=0.000; OS: HR(95%CI):0.458(0.22-0.954), P=0.037] were the independent risk factors for the PFS and OS of patients with advanced NSCLC. The gene discussed is CD274; the disease is non-small cell lung carcinoma.