ADCC has been reported to play a role in lowering the risk of and protecting from HIV-1 infection in preclinical (5–7) and clinical studies (8–10) through recruitment of NK cells via the low affinity receptor that binds to the Fc portion of IgG, FcγRIIIa (CD16) or RM FcγRIII, the homologue for human FcγRIIIa. The gene discussed is FCGR3A; the disease is HIV-1 infection.