In contrast, the risk allele of DAB2, rs11959928, which has been associated with an increased risk of CKD in several GWAS studies [10, 12], leads to a higher expression of DAB2 protein in the proximal tubular compartment and possibly to an increased risk of interstitial fibrosis through the activation of intracellular pathway of TGF-β1 [20]. This evidence concerns the gene DAB2 and chronic kidney disease.