DCDC2 seems to regulate the canonical Wnt/β-catenin signaling pathway through a downregulation process and these loss-of-function pathogenic variants lead to an overactive Wnt signaling pathway that is known to be implicated in many kidney phenotypes such as progression of acute kidney injury to CKD, renal fibrosis in CKD, cystogenesis, podocytopathy and proteinuric CKD (Fig. 3) [44]. The gene discussed is DCDC2; the disease is renal fibrosis.