FGF23 activates fibroblast growth factor receptor 4 (FGFR4) phospholipase Cγ/calcineurin/nuclear factor of activated T cells signaling in cardiomyocytes and leads to cardiac hypertrophy and myocardial fibrosis in rodents.23 The gene discussed is FGFR4; the disease is Myocardial fibrosis.