Inhibition of the inflammatory response with corticosteroids (Liu et al., 2000), recombinant activated protein C (Chen et al., 2006) or IL‐1 receptor antagonist (Lin et al., 1997; Liu et al., 2000) has also been shown to prevent tissue injury and death, suggesting the potentially harmful effects of systemic inflammation in heat stroke. This evidence concerns the gene PROC and Heat Stroke.