The results showed that p-mTOR, p-S6, p-4EBP1 and p-70S6K (the phosphorylation of Akt, ERK and mTOR signaling pathway-related proteins) were dramatically elevated in KLC tumors compared with either KC or LC tumors (Fig. 3b). The gene discussed is EIF4EBP1; the disease is laryngotracheoesophageal cleft.