FBXL6 and hepatocellular carcinoma: Importantly, univariate and multivariate Cox survival analyses suggested that high coexpression of both FBXL6 and p-ERK (HR = 0.409, 95%CI 0.255–0.653, P < 0.001; HR = 0.584, 95%CI 0.346–0.987, P = 0.044), TNM stage (HR = 3.506, 95%CI 2.161–5.688, P < 0.001; HR = 2.041, 95%CI 1.076–3.870, P = 0.029), and recurrence (HR = 4.431, 95%CI 2.262–8.682, P < 0.001; HR = 3.436, 95%CI 1.672–7.059, P < 0.001) were independent factors for OS in HCC patients (Additional file 1: Table S10).