FBXL6 and neoplasm: Consistently, high coexpression of FBXL6 and p-ERK was associated with a high TNM stage (P < 0.001), tumor size (P = 0.029), vascular thrombosis (P < 0.001), metastasis (P = 0.002) and outcome (P < 0.001, Additional file 1: Table S9).