Moreover, we observed that LSL-KrasG12D/+;Alb-Cre mice developed more severe hepatocarcinogenesis (tumor number, tumor size and the liver/body weight ratio) than LSL-KrasG12D/+;CKO-Fbxl6KO/+;Alb-Cre mice (P < 0.01, Additional file 1: Fig. S3d–e), suggesting that the knockout of Fbxl6 attenuated KrasG12D-driven HCC tumorigenesis. This evidence concerns the gene FBXL6 and neoplasm.