ALOX5 and cancer: ALOX5 (5-lipoxygenase, 5-LO) is an enzyme responsible for the synthesis of a series of biologically active lipid signaling molecules, catalyzing arachidonic acid to produce metabolites such as 5-hydroxydodecapentaenoic acid (5-HETE) and leukotrienes (LTB4, etc.), which have been shown to be lipid mediators of inflammation in various diseases, including cancer.