Currently, 6 types of HAEnCI are recognized, based on underlying mutations of factor XII (HAE-FXII), angiopoietin-1 (HAE-ANGPT1), plasminogen (HAE-PLG, Hereditary Angioedema with the plasminogen gene mutation K330E), kininogen 1 (HAE-KNG1), myoferlin (HAE-MYOF), and heparan sulfate-glucosamine 3-O-sulfotransferase 6 (HAE-HS3ST6). This evidence concerns the gene ANGPT1 and hereditary angioedema.