Results: the data were collected from 25 patients, aged between 15 and 68 years; 88% [22/25] were female and 12% [3/25] were male; 60% [15/25] of HAE type 1 and 40% [10/25] of HAE with normal C1-INH. The gene discussed is SERPING1; the disease is hereditary angioedema.