The group will then develop pathogenicity classification rules to curate variants in genes responsible for Hereditary Angioedema with normal C1-INH (nl-C1-INH-HAE), such as F12, PLG, ANGPT1, KNG1, MYOF, and HS3ST6 (OMIM: 610618, 619360, 619361, 619363, 619366, 619367). This evidence concerns the gene PLG and hereditary angioedema.