That stem cell transcriptional signature activation may represent an important event in CAF activation is sustained by literature data [63] which described an interesting molecular mechanism whereby the up-regulation of the TF SOX2, a known master regulator of lineage cell plasticity [104], leads to the reprogramming of colonic fibroblasts to support the tumor progression of human CMS4, the most aggressive colorectal cancer subtype. This evidence concerns the gene TF and neoplasm.