Since the release of damage-associated molecular patterns (DAMPs), such as HMGB1 and oxidized mtDNA, from oxidatively damaged cells induces recipient innate immune system activation via aseptic inflammation, which exacerbates damage to heart grafts, we next evaluated the role of CoQ10@TNPs in inducing recipient innate immune system activation in the HT model. The gene discussed is HMGB1; the disease is hematocrit.