Nevertheless, it is important to recognize that although the presence of pTau is considered an early event, further study is required to determine whether blocking Sarm1 may indeed interrupt the formation of small, soluble oligomeric tau species and their aggregation into larger insoluble filaments known as neurofibrillary tangles, which represent the pathological hallmark of tauopathies [28]. This evidence concerns the gene MAPT and tauopathy.