IFNB1 and viral infectious disease: Additionally, Shen et al. [80] discovered that the capsid protein (Cap) of porcine circovirus 3 (PCV3) could interact with the transactivation domain of STAT2, hindering the the expression of IFN-β and preventing the defense against viral infection and inflammation by binding to ISRE and prevent the ISRE of IRF 9-S2C.