Cluster 2 tumours are characterised by aberrant kinase signalling due to variants in genes such as NF1, RET, HRAS, MAX and TMEM127. Recently, somatic variants in CSDE1 and in-frame RNA fusion transcripts of the UBTF-MAML3 genes that activate Hedgehog and Wnt pathways have been identified, comprising Cluster 3 [1]. The gene discussed is RET; the disease is neoplasm.