CD8A and multiple sclerosis: Considering the “outside-in” paradigm of the pathophysiology of multiple sclerosis, which proposes that pathogenic T cells are activated in the periphery and then cross the BBB [35], we analyzed the spleen and inguinal lymph nodes of EAE mice 72 h after receiving or not SuperMApo and observed only marginal differences in terms of percentages (not shown) and absolute numbers of total Th1, Th17 and Treg cell subsets, as well as CD8+ T cells and Tc1 cell subset in both lymphoid organs (Fig. 2a, b).