IGF1 and colitis: The secretome of pro-resolving factors released by macrophages after efferocytosis contains a large number of molecules including chemokines (CCL5, CXCL2, and CCL22), anti-inflammatory cytokines (IL-1RA, IL-10, and TGF-β) [26], growth factors (TGF-β, IGF-I and VEGF) [27], enzymes, metabolites and polyunsaturated fatty acids, that have been demonstrated to endow a therapeutic activity to control experimental collagen-induced arthritis [26], dextran sodium sulfate (DSS)-induced and T cell transfer-induced colitis [27].