TNF and Sepsis: Previous research has indicated that sepsis typically involves the activation of the innate immune system, which includes factors such as the tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, and interferon-γ (IFN-γ), as well as the acquired immune system, which manifests in the form of apoptosis of immune cells, specifically dendritic cells (DCs), natural killer cells, lymphocytes, neutrophils and antigen-presenting cells (APC) [6–8].