Plasma LRG1 had an AUC of 0.79 (95% CI 0.73 to 0.86) when patients with early stage PDAC were compared with healthy controls and AUC of 0.68 (95% CI 0.59 to 0.78) when compared with patients with chronic pancreatitis. This evidence concerns the gene LRG1 and chronic pancreatitis.