Two conditions worth special mention are (1) membranous nephropathy occurring with IgG4 antibodies to CASPR2 and LGI1, which are associated with neurological problems although an association with membranous nephropathy does not appear to have been reported previously [14], and (2) Wolcott–Rallison syndrome. The gene discussed is LGI1; the disease is membranous glomerulonephritis.