Indeed, p140Cap is able to reduce cancer cells aggressiveness through specific molecular mechanisms, such as the down-regulation of Src kinase activity [25], and the Rac-Tiam1 axis [5, 22, 27], or by inhibiting the β-Catenin activity in cancer stem cells and modulating the immune tumor microenvironment [30, 31]. The gene discussed is SRCIN1; the disease is cancer.