ERBB2 and invasive breast carcinoma: Moreover, we also used two pre-clinical syngeneic mouse models, the TUBO cells, an established cell line from BALB/c-MMTV-NeuT mice, which is a model for Her2+ human BC [33], and the 4T1 cells, an highly tumorigenic and invasive mammary carcinoma model for stage IV human BC [48] (see Supplementary Fig. 1A).