The analysis of in vivo tumors, obtained by orthotopically injection of TUBO mock or 140Cap cells in Balb-c mice, showed the up-regulation of the HMGCR in p140Cap tumors compared to mock tumors of the same volume (approximately 500 mm3) (Fig. 2B), indicating that the p140Cap-dependent tuning of the MVA pathway is maintained in in vivo tumor growth. The gene discussed is SRCIN1; the disease is neoplasm.