TNF and neoplasm: Consistent with the previous results, IRU CAR-T (+CsA) group showed a significantly higher frequency of IFNγ+TNFα+-secreting CAR-T cells than that in WT CAR-T (+CsA) group (Fig. 5f, g and Supplementary Fig. 11c), supporting that IRU CAR-T could better control tumour progression with CsA.