Controlling for sex and depot, we found that obesity is associated with a trend towards a decrease in the fractional number of smooth muscle cells and fibro-adipogenic progenitors (FAPs), driven by CXCL14+ and PPARG+ FAPs, and a trend towards an increase in LPL+ and LYVE1+ macrophages as well as all subtypes of adipocytes, except PRSS23+ adipocytes (Fig. 5C). The gene discussed is LPL; the disease is obesity due to melanocortin 4 receptor deficiency.