Borsotto Borsotto M M  ( 2015 2015 )  Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept . The gene discussed is KCNK2; the disease is depressive disorder.