Although, in some families, ABCG5/ABCG8 missense variants did not shown complete segregation with high LDL-C levels, our data suggest that the presence of rare variants in FH-phenocopy genes may have an impact in LDL-C levels of these individuals, not as cause of FH but leading to a hypercholesterolemic phenotype. Here, ABCG5 is linked to familial hyperaldosteronism.