In fact, a rare deletion in APOE gene p.Leu167del (10) and also biallelic pathogenic variants in LDLRAP1 (11), LIPA (12), ABCG5, or ABCG8 (13) genes have all been reported in individuals with clinical FH phenotype with markedly elevated LDL-C levels. Here, LIPA is linked to familial hyperaldosteronism.