LRP6 and cancer: Remarkably, when analyzed in details (Supplementary Fig 5), among the above-mentioned cancer related pathways we found only 20 associated genes to be uniquely upregulated in 9S1R-NulloPT treated tumors (Supplementary Fig 5 A–C) including pan-cancer related genes such as Shc-1 [53], Mtor [54], Lrp6 and Wnt5a [55].