SP100 and cancer: Moreover, according to the single-cell analysis of ocular melanoma samples (Supplementary Figure S9A, GSE139829, using CancerSEA platform (38)), SP100 expression is related to a decreased score of cancer-activation hallmarks, including invasion (R = –0.33, P< 0.001), metastasis (R = –0.28, P< 0.001), cell cycle activation (R = –0.19, P< 0.001), proliferation (R = –0.16, P< 0.001) and epithelial-to-mesenchymal transition (R = –0.16, P< 0.001).