STING1 and neoplasm: To understand how ENPP1WT-OE 4T1s promote immunosuppressive phenotypes in primary tumor-resident TAMs despite increased ISG expression in these cells, we examined the activation status of the extracellular adenosine (eADO) pathway: a potential STING-independent downstream effect of cGAMP hydrolysis (SI Appendix, Fig. S5A).