As cGAS is rarely inactivated in cancer cells (17) and there is no known intracellular cGAMP hydrolase (30), we bring forward a model that cancer cells export the high levels of cGAMP they produce, capitalizing on both cancer-cell- and responder-cell-derived ENPP1 for its extracellular clearance, to achieve immune evasion. This evidence concerns the gene CGAS and cancer.