Multivariate analysis of 1097 tumor samples in the TCGA dataset showed a significant correlation between TFRC and markers of proliferation, such as MKI67 (Ki67), CCNB1, CCNA2, CDK2, CDK6, TOP2A, and TOP1 (P<1E-20, r>0.3). The gene discussed is TOP2A; the disease is neoplasm.