ANGPT2 and Sepsis: In their statistical modellings, Wollborn and colleagues derived a scoring system (“CLS-Score”) which involved seven parameters: ultrasound echogenicity to determine the degree of edema, the Sepsis-related organ failure assessment score (SOFA) score for disease severity, Ang-2, syndecan-1, ICAM-1, lactate, and the proinflammatory cytokine interleukin-6 [1].