Mascanfroni ID et al. [15] confirmed that the synthesis of IL-6, IL-12, and IL-23 in dendritic cells from the spleen of IL-27Rα−/−mice derived from experimental autoimmune encephalomyelitis (EAE) increased, while the secretion of IL-10 decreased, which promoted Th1 and Th17 immune responses and aggravated the infiltration of inflammatory cells in the central nervous system. This evidence concerns the gene IL6 and experimental autoimmune encephalomyelitis.