The mir-501-3p-CDK2 axis increases WTAP expression in RCC tissues, enhancing the stability and expression of S1PR3 mRNA in an IGF2BPs-dependent manner, thereby driving renal cell carcinogenesis, metastasis and overall poor survival through the regulation of the PI3K/Akt signaling pathway [218–220]. Here, WTAP is linked to renal cell carcinoma.