Similarly, reduced METTL14 was revealed to promote the translation of P2X6 mRNA, activate the ATP-P2X6-Ca2 + -p-ERK1/ERK2-MMP9 signaling pathway, translate into cell migration and invasion, and is detrimental to the prognosis of RCC [216]. The gene discussed is P2RX6; the disease is renal cell carcinoma.