Xie et al. employed MeRIP and found that the METTL3/YTHDF2 m6A axis directly degrades the mRNAs of tumor suppressors SETD7 and KLF4 and promotes BCa development, whereas METTL3 depletion contributes to the impairment of cancer proliferation and metastasis [198]. This evidence concerns the gene METTL3 and cancer.