YTHDF2 and neoplasm: Further analysis of MeRIP-seq, mRNA-seq, and databases identified LHPP and NKX3-1 as the main targets of YTHDF2, while LHPP and NKX3-1 were found to be tumor suppressors regulating tumor progression by inhibiting AKT phosphorylation [163–167], which was also reported by Cai et al. where METTL3 had elevated levels in PCa cells, promoting its growth by regulating the hedgehog pathway [160].