HRG and kidney cancer: It was also demonstrated that enhancement of mucin 15 (MUC15) and m6A modification of histidine-rich glycoprotein (HRG) mRNA using dCas13b-M3M14 fusion protein inhibited the metastasis of kidney cancer, further confirming the role of METTL3 and METTL14 in kidney cancer and providing a potential intervention strategy [217].