Deletion of the miRNA cluster (pre-miR-1-9 and -11) significantly reduced the level of IL-1α transcript, and overexpression of the miRNA cluster alone in MM cells was sufficient to significantly increase the IL-1α expression (Fig. 6A and B), indicating that the miRNA cluster contributed to KSHV induction of IL-1α. Here, IL1A is linked to Miyoshi myopathy.